Nasal Esketamine

Esketamine for Depression

We offer the only FDA-approved ketamine-based treatment for depression. Nasal esketamine (Spravato®), is a safe, physician-supervised, psychedelic nose spray therapy that is covered by many insurances. Often, nasal esketamine is effective at treating depression in patients who have been unable to find relief through other methods, like talk therapy and antidepressants. Learn more about esketamine treatment and determine if it might be right for you.

How does it work?

It is believed, based on the current research, that Ketamine disrupts the brain chemical glutamate. Glutamate is involved vvith learning, memory, emotion, and pain recognition. Ketamine can cause rapid heart rate and elevated blood pressure.

Esketamine is a part of ketamine, and was made to be more potent in its nasal form, so you can use this medication at a lower dose and, likely, have fewer side effects.

Esketamine must be used in conjunction with a conventional antidepressant and is regulated through a federally mandated risk mitigation program. Esketamine can provide rapid relief from depression symptoms and suicidality.


Learn more about Esketamine.

Esketamine is made from a drug called ketamine, which was first used in clinical practice as an anesthetic (sedative). In the 1970s, ketamine's use for the treatment of psychiatric disorders was first noted and has been studied formally since the 1990s. In 2019, the FDA approved nasal esketamine, a ketamine-based nasal spray for adults with treatment-resistant depression (TRD) and adults with major depressive disorder (MDD) - sometimes called Clinical Depression - with suicidal thoughts or behavior. TRD simply means that standard treatment methods have not been able to successfully treat the depressive episode.

Although you may have also heard of ketamine as a psychedelic street drug with names such as 'Special K' or 'K', its use can be safe when under the supervision of a trained clinician. To learn more, check out our Esketamine: VIDEO BLOG POST - Busting the Myths, where we dispel some of the most common misconceptions about this medication.

Is Esketamine (Spravato®) right for me?

Esketamine is not right for everyone. However, for the right people, it shows great promise. We would love for you to speak with a member of our Interventional Services Team to see if Spravato (Esketamine) might be a good fit. Please complete this screening questionnaire and a team member will reach out to you.

If you've tried other depression treatments (medications, therapy, TMS, or even ECT) without success, there is still hope. In fact, most of our patients have tried several types of treatments before finding success with nasal esketamine.


Covered by many
insurance plans


FDA-cleared and


Knowledgable and
experienced staff

Environment Image

Treatment in a safe and comfortable environment.

Your comfort and safety are our top priortities. Since esketamine, like ketamine, is a psychedelic treatment, you may experience feelings like euphoria, dizziness, or intoxication. Our expert care team will be available onsite, and will also closely monitor you and your blood pressure throughout treatment. Learn more about esketamine treatment, including what to expect and how to prepare.

Typical Course of Treatment

Each patient is unique and will receive their own individualized care plan. However, the treatment course for nasal esketamine typically starts with two treatments per week for the first four weeks, followed by one treatment per week for four to eight weeks, before being reduced. The goal is to reduce treatment frequency to once per month. Esketamine must be used in conjunction with a conventional antidepressant.


2 treatments per
week for 4 weeks


1 treatment per
week for 4 to 8 weeks


1 treatment every
3 to 5 weeks


2 treatments per
week for 4 weeks


1 treatment per
week for 4 to 8 weeks


1 treatment every
3 to 5 weeks

Esketamine & Ketamine: Busting the Myths

Learn more about ketamine and nasal esketamine in our blog post, Esketamine: Busting the Myths.

Check out our blog.

We strive to educate, empower, and inspire patients to help them lead happier, healthier lives. Check out our blog for news and helpful information, expert tips, answers to some of your most frequently asked questions, and much more.

Understanding Mental Illness

Mental Illness = Brain Disease To explain mental Illness, it makes sense to look at other illnesses that affect the human body. Hypertension, also called High Blood Pressure, […]

Transcranial Magnetic Stimulation (TMS) FAQs

TMS is a safe, non-drug, FDA-cleared treatment that uses gentle magnetic pulses to stimulate underactive areas of the brain, helping to better regulate mood in patients with depression. […]

Ketamine & Esketamine: Busting the Myths

The drug, ketamine, comes in a variety of forms, potencies, and uses. For example, the medical community often uses it at high doses as an anesthetic and/or to […]

Insurance Coverage TMS Treatment of OCD

TMS is approved for the treatment of OCD and is expanding insurance coverage options!  Call our office today if you are interested!

Predicting response to TMS; we expect it 90% of the time

IMAGES: Blue image shows reduced Ge R, Downar J, Blumberger DM, Daskalakis ZJ, Vila-Rodriguez F.  Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in […]

Dr. Becker joins NeuroScience & TMS Treatment Centers

Depression help-quickly!

DEPRESSION HELP – quickly.  The NeuroScience & TMS Treatment Center is committed to improving processes, to help YOU get help for depression, quickly.  Being a full-service psychiatric clinic, […]

Staying Safe while we care for YOU

Everyone at the NeuroScience & TMS Treatment Centers joins me in our concern for the safety of you, our staff, and all the world. After working virtually except […]


by Ali T. Self, LMSW So, how are you doing out there?  We are living in an unprecedented time.  It is very weird and wild.  Tornadoes and then […]

Staying safe

Long before the panic of COVID -19 infections peaked in Nashville, the NeuroScience & TMS Centers had safety as a priority.  Our TMS operators and staff are certified […]


Physician Recommended.
Patient Preferred.

Dr. Cochran at The Neuroscience and TMS center has served as my psychiatric care physician for the past 5 years. I have made tremendous progress while seeing her. She is attentive, thorough, and professional. I refer her to everyone I know in need of psychiatric care because I trust her and her staff completely. I am very thankful to be a patient of the Neuroscience and TMS center.


This hands down is the BEST doctor’s office I've ever been to. Not just on a psychiatric level, but just a medical setting in general. I love Dr. Becker and I'm beyond grateful that I found him. He is very personable and just one of the easiest people to talk to. And the front desk is great too and that goes a long way! So yes, 5 stars! I recommend this to anyone who needs to find a good and relaxed environment for psychiatry.


Mary is wonderful. She understands my medical condition and truly cares. She listens and comforts you in time of need. She is a true human being and doesn’t treat you like a number. She is very professional and knows her stuff.


Ali was amazing. We have searched for help for years for our son. It was nice for her to listen but then give great advice!! We are in the process of implementing her parenting plan and It is not easy but we can already see a difference!!


This was a great treatment for me. I have completed TMS therapy numerous times b/c I keep getting better and better. I suffered a traumatic brain injury and was steered towards TMS and it has helped me tremendously…This team knows what they are doing and I’m happy I had the opportunity to do this.


The staff are 100% committed to the clients’ health and well-being. They find solutions tailored to the individual’s needs and goals. If I could leave 10 stars, I would. ⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️


Everyone from Dr. Becker on down has done an outstanding job. Professional and caring that is hard to find in medicine today and you guys provide both!! And, Emily is a real gem as the TMS tech.



We are here for you.

Want to learn more about one of our treatments or services?
Need to schedule an appointment or have a question about your care plan? We're here for you! To reach any office

Call 615.224.9800


Secure Text Line (615) 551-5853

Fax (615) 224-9840, or

Complete the Form Below

Scroll to Top